Joint Reaction
Joint Reaction Seminars
1st January 2024
Joint Reaction
Joint Reaction Seminars
1st January 2024

Pioneering, Life-changing Treatment For Knee Osteoarthritis


Pioneering, Life-changing Treatment For Knee Osteoarthritis

Osteoarthritis of the knee is the most common form of arthritis and it’s incidence is rising. The most effective surgical treatment for the pain caused by osteoarthritis is a joint replacement. This is major invasive surgery associated with a prolonged recovery period.

James Singleton and Zu Nawaz can offer an alternative, non-surgical option. Arthrosamid® is a new class of injectable therapy to treat adults with knee osteoarthritis. It is a single-dose injection that delivers long acting and sustained pain relief, improving the quality of life for patients with knee osteoarthritis.

How does Arthrosamid® work?
Arthrosamid® is a hydrogel made up of 2.5 percent cross-linked polyacrylamide and 97.5 percent water. Arthrosamid® combines with the synovial tissue in the knee to form a permanent scaffold 4, and it’s this unique characteristics that provides a significant reduction in OA pain over a Longer period (5,6,7,8)– with one single treatment (9)


As a consultant who sees many patients suffering from Osteoarthritis of the knee, I am excited that we can offer this pioneering, life changing treatment at Spire Clare Park. Whilst knee replacement surgery yields excellent results it is not always appropriate for everyone. Therefore, having this unique product provides me with another cutting edge solution for a life changing condition that potentially avoids surgery

Zu Nawaz

There has been little successful innovation in treating osteoarthritis over the past twenty years, and until now, apart from surgery, there are few treatment options that can provide long-term benefit to patients. I am thrilled to be able to offer this highly promising new product to change the landscape for treating debilitating knee arthritis

James Singleton



  • Statistically significant reduction in pain maintained at three years.1
  • Undergone over 20 years of research and development.2
  • Arthrosamid® is safe for intended use.3
  • Over 1,000,000 hydrogel injections have been given so far.2


  1. Henriksen, M. et al. (2023). 3-year results from a prospective study of polyacrylamide hydrogel for knee osteoarthritis. Osteoarthritis and Cartilage, Vol 31(5): P682–683. DOI:10.1016/j.joca.2023.02.023.
  2. Data on file.
  3. Overgaard, A., et al. (2019). Safety of intra-articular polyacrylamide hydrogel for the treatment of knee osteoarthritis symptoms: A retrospective case series. Clin Ortho Adv Res. Osteoarthritis and Cartilage Vol.30, Supplement 1, S370-S371. DOI:10.1016/j.joca.2022.02.497.
  4. ChristensenL,et al (2016) Histological appearance of Synovial Membrane after treatment of Knee Osteoarthritis with Polyacrylamide Gel Injections: A Case Report. Journal of Arthritis. Vol 5:217
  5. Bliddal, H., et al. (2021). Polyacrylamide Hydrogel Injection for Knee Osteoarthritis: A 6 Months Prospective Study. J Orthop Res Ther. 6(2). 1188. ISSN 2575-8241.
  6. Bliddal, H., et al. (2022). One-year performance of polyacrylamide hydrogel vs. hyaluronic acid: A randomised controlled study. Osteoarthritis and Cartilage. Vol 30(1): S370-71. DOI:10.1016/j.joca.2022.02.49
  7. Bliddal, H., et al. (2023). A prospective Study of Polyacrylamide Hydrogel injection for Knee Osteoarthritis: results from3 years after treatment. Osteoarthritis and Cartilage. Vol 31(5): S682-683.
  8. Bliddal, H., et al. (2024).3 follow up from a randomised controlled trial of intra articular polyacrylamide hydrogel injection in subjects with knee osteoarthritis poster LB-31. OARSI 2024.
  9. Arthrosamid, Instructions for Use. Release Date March 2022 10082-003

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Pioneering, Life-changing Treatment For Knee Osteoarthritis
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